【Reference】 Chinese medicine treatment of osteoporosis

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Original Address: 【Reference】 text of Chinese medicine treatment of osteoporosis: Xinyu Ming

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Original Address: Chinese text of the treatment of osteoporosis: health division

◆ Epimedium ◆

Weixin, sweet, and warm, the liver, kidney. modern pharmacological experiments showed that water extract of Epimedium total effective area and its application to the Castration-dimensional A acid, adrenal cortex hormones and hydroxyurea in rats caused by OP model are have some role in prevention and treatment, its mechanisms and improve bone metabolism, regulate the levels of enzymes and hormones promote protein synthesis, nucleic acid metabolism and enhance the hypothalamus - pituitary - gonadal axis and adrenal axis, thymus axis related to the function such as secretion system . 5 mg ml -1 aqueous extract of Epimedium can promote the proliferation of osteoblasts, but the differentiation of osteoblasts had no effect. icariin Monomers which can promote osteoblast differentiation and mineral features, and can promote bone marrow stromal cells into osteoblasts, the level of the gene for BMP2-mRNA expression. Epimedium times glycosides Ⅰ, Epimedium times glycosides Ⅱ, Epimedium set B, set Epimedium C also has to promote in vitro osteoblast proliferation and mineralization. In addition, Epimedium also dose dependently inhibited the formation of bone marrow cells differentiated osteoclast-like cells and inhibit bone resorption. in recent years has been suggested by inhibition of adipogenic differentiation of bone marrow stromal cells and promote their osteogenic differentiation to achieve prevention and treatment of OP's point of view. Recently, the Chinese Academy of Medical Sciences Peking Union Medical College Institute of Medicinal Plant Research Institute, Shenzhen City University of Hong Kong studied 95% Epimedium Extraction of ethanol extract of various parts (including petroleum ether, chloroform, ethyl acetate, butanol) and 50% ethanol extract, water extract some bone on bone marrow stromal cells differentiation, and found some with ethyl acetate promote osteogenic differentiation of.

◆ Drynaria ◆

and warm, bitter, kidney, liver. There kidney, blood, bleeding, continued injury The effectiveness of commonly used drugs for the bone-setting. the whole animal study found that Drynaria prevention and treatment can significantly OP. Drynaria water extract and alcohol extract could promote mouse osteoblastic cell line MC3T3-E1 proliferation, differentiation and mineralization. Overseas research has shown that isolated from Drynaria monomer (such as flavan -3-- alcohol) can promote human breast cancer cells MCF-7 and the proliferation of osteoblast-like cells in the role of ROS17/2.8 , the proliferation of even more than the estradiol and genistein, suggesting that there Gusuibu the role of estrogen-like compounds, and thus have therapeutic effects in postmenopausal OP. In addition, Drynaria extract can inhibit osteoclastic bone bone resorption, specifically in the number and area of bone resorption showed a dose-dependent reduced. The role of osteoclasts may be through inhibition of intracellular mature cathepsin K, the sky, the inhibitory effect and concentration-dependent relationship.

◆ Cnidium ◆

warm non-toxic, taste hard, in the final kidney. with kidney impotence, dampness, expelling wind, the role of pesticides. snake Chuangzai contain coumarins were considered to have weak estrogen-like biological effects. Series results show that the total coumarins can use Cnidium glucocorticoids and OP caused by ovariectomy model has obvious therapeutic effect This may be related to the promotion of osteoblast proliferation and secretion of alkaline phosphatase, inhibiting the secretion of osteoblasts NO, interleukin (IL) -1 and IL-6 related. Another study shows that the total coumarins through Cnidium inhibition of osteoclast differentiation and bone resorption and thus play a protective role. molecular level, studies have shown that osthole can increase osteoblast OPG (OPG) expression, while a slight inhibition of RANKL (also said ODF, osteoclast differentiation factor) expression.

◆ Dipsacus ◆

of bitter lukewarm, sweet Sim, the liver, kidney. with liver and kidney, strengthening the bones and blood, continued off injury, only uterine bleeding, miscarriage and other effects. Modern research shows that, Chuan-off can be reversed due to bone loss in ovariectomized rats. 95% ethanol and 50% ethanol extract can dose both to promote the proliferation of osteoblasts, and the effect of promoting proliferation of the former is stronger than the latter.

◆ psoralen ◆

of Greater Vancouver, bitter, acrid, spleen, kidney by. with kidney impotence, urinary solid minified, Wenpi antidiarrheal effect. pharmacological experiments showed that psoralen acetone extract can increase the non-polar bone strength, increase blood levels of inorganic phosphate. In vitro experiments showed that ethanol extracts psoralen, ethyl acetate monomer in the extraction of parts of its flavonoids psoralen and psoralen A Su Ning could promote osteoblast-like cells UMR106 proliferation and differentiation. psoralen also can inhibit osteoclastic bone resorption pit formation and expansion, and the inhibitory effect of psoralen concentration.